Welcome to our website! Working Hours: Mon-Sat 10:00-20:00 / info@akisthemes.com
Welcome to our website! Working Hours: Mon-Sat 10:00-20:00 / info@akisthemes.com

Pre-Clinical Studies

Pre-Clinical Studies

1) Toxicity studies: Conduct of various toxicity studies including acute toxicity, dermal irritation, skin sensitization, local tolerance, six pack acute toxicity, repeat dose sub-acute toxicity studies in rats, mice, rabbits and guinea pigs required for drug discovery, active pharma ingredients (Raw Materials), finished formulations, vaccines, biological, biotech products, recipients, additives and intermediates, natural extracts, pesticides, medical devices.

2) Pathology: Preparation of histopathology slides and microscopic evaluation, hematology, clinical chemistry estimations, urinalysis. Pathology interpretations and report preparations.

3) Microbiology: Conducting the Genetic Toxicology studies including Ames (mini Ames assay), Micronucleus test.

4) Ecotoxicology: Conducting toxicity studies in aquatic species and earthworms.

Type of studies

Acute Toxicity Studies

Types: Dermal Irritation/Corrosion, Skin Sensitization, Local Tolerance, Six pack acute studies
Species: Rat/ Mice/ Rabbit/ Guinea Pig
Routes: Oral / Dermal / Subcutaneous / Intramuscular / Intraperitoneal/or as per requirement

Repeat Dose Studies

Types: 14-day toxicity, 28-day toxicity, 90-day and chronic toxicity studies
Species: Rat/ Mice/ Rabbit
Routes: Oral / Dermal / Subcutaneous / Intramuscular / Intraperitoneal/or as per requirement

Genotoxicity Studies

AMES assay (Bacterial Reverse Mutation Test with Salmonella)
In vivo Micronucleus Test in mouse (Mammalian erythrocyte micronucleus test)

Chronic toxicity studies

Reproduction studies as per ICH Guidelines
Fertility and early development study in rats
Embryo-fetal developmental study in rats or mice and rabbits